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SELECT 
  1 
FROM 
  tmall_lock_keys 
WHERE 
  key_id = '6cadfb1e109f1b069ccee1050bb5dfd6411bf72b3fd048cadc8eaa8566ed65c5' 
  AND token = 'HXsqCGk9YobI+6i+aGRhxivY7OUGZE2fYJOySXMvElI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00777

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}