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SELECT 
  1 
FROM 
  tmall_lock_keys 
WHERE 
  key_id = '8b0a644e6f62342a555134e02325792b98164527102daedaad4859129ffb16f6' 
  AND token = 'sxrTZvMo3BPdhC13uoqeNZPxHT8B4g+HYZrZL0KKE8E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.01004

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}