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SELECT 
  1 
FROM 
  tmall_lock_keys 
WHERE 
  key_id = '8b4145678255c4ec9aeb281faf60acc2789354e033dad46d58775d7b6c5d63ea' 
  AND token = '59Z4ZN3SAcTfUNY/j2TSMbSish/csPzAgZ29a0zYeE8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00847

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}