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SELECT 
  1 
FROM 
  tmall_lock_keys 
WHERE 
  key_id = '437c9c51b16301e290668c76e26414c31636721e47ca791da27d18a5acba65be' 
  AND token = 'IKdFIKwNX9w6WLhpErSqNKzUBCp4HKUqPAg2atpb1Do=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00827

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}