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SELECT 
  1 
FROM 
  tmall_lock_keys 
WHERE 
  key_id = '49d4cd4e6616335a718f72579f1527fd144674fe74c44dbda2d33ed738e5f0cc' 
  AND token = 'O3XxDiSZutsCp51PskuSjfSGMHDhaYZNo9PY4rWv5mQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00739

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}